Preserved otolith organ function in caspase-3-deficient mice with impaired horizontal semicircular canal function

Decline in semicircular canal and otolith function with age.

OBJECTIVE To characterize the physiologic nature of the vestibular dysfunction that occurs with the normative aging process. STUDY DESIGN Cross-sectional study. SETTING Tertiary care academic medical center. PATIENTS Fifty individuals age 70 years and above. INTERVENTIONS Head thrust dynamic visual acuity testing and cervical and ocular vestibular-evoked myogenic potential (VEMP) testin...

Enhanced otolithic function in semicircular canal dehiscence.

The enhanced sound- and vibration-induced vestibular evoked myogenic potentials (VEMPs) and their lower threshold in patients with a thinning of the bony wall of the superior semicircular canal (superior canal dehiscence, SCD) have been interpreted as being due to the dehiscence allowing sound and vibration to activate, unusually, the receptors of the dehiscent semicircular canal. We report a p...

Anterior canal failure: ocular torsion without perceptual tilt due to preserved otolith function.

A patient with anterior semicircular canal dehiscence syndrome underwent surgical patching that caused an isolated dysfunction of the left anterior semicircular canal postoperatively. He exhibited significant ocular torsion toward the side of the affected labyrinth (17 degrees excyclotropia of the ipsilateral eye), but no displacement of the subjective visual vertical. This dissociation suggest...

Isolated Unilateral Horizontal Semicircular Canal Malformation

Semicircular Canal Fibrosis as a Biomarker for Lateral Semicircular Canal Function Loss

BACKGROUND AND PURPOSE Radiological abnormalities at the level of the semicircular canals are frequently observed without known correlation to a pathologic condition or function. They include narrowing or sclerosis on computed tomography (CT) and narrowing or signal loss on T2-weighted magnetic resonance imaging (MRI). Our hypothesis was that these radiological abnormalities at the level of the...